After coming under pressure for an incredibly defensive display away to Liverpool last weekend, Jose Mourinho will be hoping his side can rediscover their attacking flair when they travel to 12th place Huddersfield.
Huddersfield:
David Wagner's side could receive a much needed boost in the return of Steve Mounie, who is in line for a starting place after missing the last four league games with a heel injury.
The extent Philip Billing's ankle injury that he picked up against Swansea is yet to be determined, while long-term absentees Collin Quaner, Kasey Palmer and Michael Hefele remain sidelined.
Manchester United:
Despite limping off in United's Champions League win against Benfica on Wednesday, Marcus Rashford will be in contention for a place in Jose Mourinho's starting XI.
Phil Jones could make a return to Premier League action, but Michael Carrick, Marouane Fellaini, Paul Pogba, Zlatan Ibrahimovic, Marcos Rojo and Eric Bailly all miss out with injuries.
Recent form:
Possible lineups:
Huddersfield: Lossl; Smith, Zanka, Schindler, Malone; Hogg, Williams; Kachunga, Ince, Van La Parra; Depoitre
Man United: De Gea; Valencia, Smalling, Lindelof, Darmian; Herrera, Matic; Rashford, Mkhitaryan, Martial; Lukaku